MRSA virulence and spread

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Genome and virulence determinants of high virulence community-acquired MRSA.

BACKGROUND A new type of meticillin-resistant Staphylococcus aureus (MRSA), designated community-acquired MRSA, is becoming increasingly noticeable in the community, some strains of which cause fatal infections in otherwise healthy individuals. By contrast with hospital-acquired MRSA, community-acquired MRSA is more susceptible to non b-lactam antibiotics. We investigated the high virulence pot...

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Evolution of MRSA during hospital transmission and intercontinental spread.

Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals t...

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[Prevention of MRSA spread in the neurosurgical field].

We investigated the distribution of MRSA (methicillin-resistant Staphylococcus aureus) on and around six patients with MRSA infection in our neurosurgical ward. All patients had a disturbance of consciousness and had sputum colonization of MRSA. Samples were obtained from 11 sites (patients' hands, attendances' hands, floors, sidetables, bedclothes, chairs, walls, curtains, door knobs, faucets ...

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Prevention of MRSA spread in the neurosurgical field

Infection control was examined for 8 examples in which MRSA (Methycilin-Resistant Staphylococcus Aurous) from squint was detected in a neurosurgical ward. The stamp method was utilized for this MRSA infection research and analysis. Samples were gathered from a ward, patient environment and medical stafL uniforms. After those samples were collected, they were cultivated and identified. In additi...

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Predicting the virulence of MRSA from its genome sequence.

Microbial virulence is a complex and often multifactorial phenotype, intricately linked to a pathogen's evolutionary trajectory. Toxicity, the ability to destroy host cell membranes, and adhesion, the ability to adhere to human tissues, are the major virulence factors of many bacterial pathogens, including Staphylococcus aureus. Here, we assayed the toxicity and adhesiveness of 90 MRSA (methici...

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ژورنال

عنوان ژورنال: Cellular Microbiology

سال: 2012

ISSN: 1462-5814

DOI: 10.1111/j.1462-5822.2012.01832.x